A roadmap for gene functional characterisation in crops with large genomes: Lessons from polyploid wheat

Understanding the function of genes within staple crops will accelerate crop improvement by allowing targeted breeding approaches. Despite their importance, a lack of genomic information and resources has hindered the functional characterisation of genes in major crops. The recent release of high-quality reference sequences for these crops underpins a suite of genetic and genomic resources that support basic research and breeding. For wheat, these include gene model annotations, expression atlases and gene networks that provide information about putative function. Sequenced mutant populations, improved transformation protocols and structured natural populations provide rapid methods to study gene function directly. We highlight a case study exemplifying how to integrate these resources. This review provides a helpful guide for plant scientists, especially those expanding into crop research, to capitalise on the discoveries made in Arabidopsis and other plants. This will accelerate the improvement of crops of vital importance for food and nutrition security.

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  • Name: Adamski, Nikolai M, Type: Corresponding Author,
  • Name: Borrill, Philippa, Type: Author,
  • Name: Brinton, Jemima, Type: Author,
  • Name: Harrington, Sophie A, Type: Author,
  • Name: Marchal, Clémence, Type: Author,
  • Name: Bentley, Alison R, Type: Author,
  • Name: Bovill, William D, Type: Author,
  • Name: Cattivelli, Luigi, Type: Author,
  • Name: Cockram, James, Type: Author,
  • Name: Contreras-Moreira, Bruno, Type: Author,
  • Name: Ford, Brett, Type: Author,
  • Name: Ghosh, Sreya, Type: Author,
  • Name: Harwood, Wendy, Type: Author,
  • Name: Hassani-Pak, Keywan, Type: Author,
  • Name: Hayta, Sadiye, Type: Author,
  • Name: Hickey, Lee T, Type: Author,
  • Name: Kanyuka, Kostya, Type: Author,
  • Name: King, Julie, Type: Author,
  • Name: Maccaferrri, Marco, Type: Author,
  • Name: Naamati, Guy, Type: Author,
  • Name: Pozniak, Curtis J, Type: Author,
  • Name: Ramirez-Gonzalez, Ricardo H, Type: Author,
  • Name: Sansaloni, Carolina, Type: Author,
  • Name: Trevaskis, Ben, Type: Author,
  • Name: Wingen, Luzie U, Type: Author,
  • Name: Wulff, Brande BH, Type: Author,
  • Name: Uauy, Cristobal, Type: Author,
Maintainer Email
Article Host Type publisher
Article Is Open Access true
Article License Type cc-by
Article Version Type publishedVersion
Citation Report https://scite.ai/reports/10.7554/elife.55646
DFW Organisation NIAB
DFW Work Package 3
DOI 10.7554/elife.55646
Date Last Updated 2020-11-30T15:50:04.716105
Evidence oa journal (via doaj)
Funder Code(s)
Journal Is Open Access true
Open Access Status gold
Publisher URL https://doi.org/10.7554/elife.55646